Li-Huei Tsai tweet on hippocampus recognising image sequences top tweet in Q3 2021
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The Clinical Trial Arena lists five of the most popular neurology tweets in the third quarter of 2021, based on data from GlobalData's Pharmaceuticals Influencer Platform.
The top tweets are based on the total engagements (likes and retweets) received in the third quarter (Q3) of 2021 on tweets from 150+ neurology professionals tracked by GlobalData's Pharmaceuticals influencer platform.
The most popular tweets about neurology in the third quarter of 2021: Top 5
1. Li-Huei Tsai's tweet on the role of the hippocampus in recognizing image sequences
Li-Huei Tsai, professor and director at the Massachusetts Institute of Technology (MIT), shared an article about a study by the institute to analyze how the mammalian brain recognizes image sequences. The study showed that individual images are preserved in the brain's visual cortex, but guidance through the hippocampus is essential to discern a sequence of sights, although the mechanism behind the process is still unknown.
The results can help neuroscientists understand how the brain integrates long-term visual memory in key brain regions. It can also help understand the role of the hippocampus in storing memory in the visual cortex, which is responsible for coding simple visual stimuli and timing.
Further results of the study indicate that in visual memory there is a clear distinction in work between simple tasks such as recognizing the image and more complicated tasks of recognizing in a sequence.
A very interesting new study by @ MIT_Picower colleague Mark Bear notes that while the visual cortex can store individual images, the hippocampus (possibly via a cholinergic circuit) is essential to memorizing them in a sequence https: // t.co/zBeOTQTMdI
-Li-Huei Tsai (@DrLiHueiTsai) July 26, 2021
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Username: Li-Huei Tsai
View all newsletters Sign up hereTwitter handle: @DrLiHueiTsai
Likes: 156
Retweets: 31
2. Earl K. Miller's tweet on neuromodulation of the cognitive function of the prefrontal cortex in primates
Earl K. Miller, Picower Professor of Neuroscience at MIT, published an article on the role of neuromodulators such as monoamines, acetylcholine, serotonin, and catecholamines in modulating the cognitive function of the prefrontal cortex in primates. The primate prefrontal cortex (PFC) is responsible for cognitive activity, but its optimal function depends heavily on a specific neurochemical environment. Loss of norepinephrine, dopamine, or acetylcholine from the dorsolateral PFC (dlPFC) can be just as damaging as removing the cortex itself. In addition, serotonergic effects are essential for the efficient functioning of the orbital and medial PFC. Studies in monkeys have found the molecular signaling pathways responsible for the production and modulation of mental representations by the dlPFC.
Research into human brain imaging also discovered the effects of drugs and genotypes on a variety of cognitive activities and the functional connectivity of the PFC circuit, including the effect of catecholamines on maintaining mental representations. The investigation of the mechanisms of neuromodulatory influences on the PFC is essential in order to find the causes of cognitive disorders and to develop effective therapeutics, the article explains in detail.
Nice rating
Neuromodulation of Cognitive Function of the Prefrontal Cortex in Primates: the Powerful Role of Monoamines and Acetylcholinehttps: //t.co/NgpsAh7p5t
- Earl K. Miller (@MillerLabMIT) August 6, 2021
Username: Earl K. Miller
Twitter handle: @MillerLabMIT
I like it: 142
Retweets: 39
3. Hugo Spiers' tweet about activity patterns of the hippocampus in humans
Hugo Spiers, director of the Spatial Cognition Laboratory at University College London (UCL), shared a study that was carried out to examine the activity patterns of the hippocampus in humans. The study researchers examined the activity patterns in a targeted navigation task to investigate the role of context and destination information in the design and implementation of navigation plans in the hippocampus.
The study showed that the hippocampus can aid planning, imagination, and navigation by creating mental maps that map the structure of physical environments, tasks, and circumstances. The results also showed that the hippocampus maintains a context-specific picture of a future goal while planning. The study showed that patterns of activity in the hippocampus are strongly influenced by context and intent, and not just represent overlapping associations.
Exciting new preprint from @jcrivdeck & co in the @CharanRanganath lab
"Goal-oriented predictive representations in the human hippocampus" https://t.co/rGK3XjeaAS
Navigation is explored through paths in animal clubs. Nice to see evidence of target coding in the hippocampus
- Prof. Hugo Spiers (@hugospiers) August 19, 2021
Username: Prof. Hugo Spiers
Twitter handle: @hugospiers
I like it: 63
Retweets: 15
4. Gavin Giovannoni's tweet about the side effects of using Amitriptyline
Gavin Giovannoni, Professor at Barts and the London School of Medicine and Dentistry, shared his article on the side effects of using amitriptyline, the first tricyclic antidepressant developed in the 1950s. The drug has both central and peripheral anticholinergic effects that interfere with cognition. It can also cause dry mouth and worsen constipation, and has been linked to excessive sedation during the day.
In addition, amitriptyline and other tricyclics increase the risk of falls and fractures in the elderly. The medicine has been associated with hypotension or low blood pressure and irregular heartbeat, and interactions with a variety of other drugs. Giovannoni warned that instead of taking amitriptyline, other drugs, such as duloxetine, with lower anticholinergic effects should be investigated.
Did you know neurologists have a dirty little secret called amitriptyline?
Do you take amitriptyline? As someone with the MS side effect profile, amitriptyline may not be in your best interest. #MS_Selfie_Newsletter https://t.co/IaNiOUxvsV pic.twitter.com/YDaHeP9a0C
- Gavin Giovannoni (@GavinGiovannoni) September 29, 2021
Username: Gavin Giovannoni
Twitter handle: @GavinGiovannoni
I like it: 48
Retweets: 17
5. David Perlmutter's tweet about how sleeping properly can prevent dementia
David Perlmutter, neurologist and president of the Perlmutter Health Center, shared an article on how sleep deprivation can cause dementia. A study of people aged 50, 60, and 70 who slept six hours or less found that they were at a higher risk of developing dementia later in life. The study examined data from more than 8,000 people over a period of 25 years.
According to the results of the study, the risk of dementia increased by 30% in all three age groups, regardless of their sociodemographic, behavioral, cardiometabolic or mental health status. Insufficient sleep also led to various other problems, including inflammation in the brain, atherosclerosis, and impaired clearance of amyloid-beta. Limiting coffee consumption, tracking sleep patterns with wearable devices, and reducing digital device use in the evening can all contribute to a good night's sleep, the article says.
Stop worrying about #Alzheimer and go to bed. I'm serious! Https: //t.co/ZndSFPTqrY
- David Perlmutter, MD (@DavidPerlmutter) August 14, 2021
Username: David Perlmutter, MD
Twitter handle: @DavidPerlmutter
Likes: 45
Retweets: 11
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